This entry represents an N-terminal helical domain of approximately 60 residues found in bacterial SAM-dependent methyltransferases. This domain is always located N-terminal to a methyltransferase domain ([pfam:PF09445], [pfam:PF13649]) and is frequently followed by a THUMP-like domain ([pfam:PF18096]). The family is found almost exclusively in Actinomycetota, particularly in Streptomyces species and related genera. The specific function of this N-terminal domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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