This entry represents a family of small proteins of approximately 67 residues found in Cyanobacteriota, predominantly in Synechococcales. One member is also found in Paulinella, a cercozoan amoeba that possesses a cyanobacterium-derived chromatophore. Structural analysis indicates these proteins adopt an SH3 barrel-like fold. The function of this family remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":17,"pathways":0,"proteins":17,"proteomes":17,"sets":1,"structural_models":{"alphafold":12},"structures":0,"taxa":54},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":27},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}