This entry represents a domain of approximately 100 residues that adopts an NTF2-like fold. This domain is often found in tandem repeats within proteins. Members are found in diverse eukaryotes including Stramenopiles and Haptophyta, as well as in some Cyanobacteriota. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0051","name":"NTF2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":27,"pathways":0,"proteins":21,"proteomes":10,"sets":1,"structural_models":{"alphafold":19},"structures":0,"taxa":61},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":20,"alignment:full":38},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}