This entry represents a C-terminal immunoglobulin-like domain of approximately 100 residues found in cyanobacterial proteins. These proteins contain an N-terminal NTF2-like domain followed by this Ig-like C-terminal domain. Proteomic studies have shown that one family member (Slr2144 in Synechocystis sp. PCC 6803) accumulates under salt stress and hexane stress conditions and is localised to the periplasm. The family is found exclusively in cyanobacteria, including Nostocales and Oscillatoriophycideae. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":242,"pathways":0,"proteins":241,"proteomes":239,"sets":1,"structural_models":{"alphafold":142},"structures":0,"taxa":644},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":101,"alignment:full":203},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}