This entry represents putative zinc-binding domain found in a family of small uncharacterised proteins of approximately 50 to 70 residues. The family is found in cyanobacteria, chlorophyte algae, stramenopiles (including diatoms), and ascomycete fungi (primarily Dothideomycetes). The presence in both cyanobacteria and photosynthetic eukaryotes suggests possible plastid-associated function or horizontal gene transfer. The function of this family remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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