This entry represents a C-terminal domain found in RHS (rearrangement hotspot) family proteins and related polymorphic toxin proteins. It is often associated with ADP-ribosyltransferase toxin domains ([pfam:PF03496]) and RHS repeats ([pfam:PF03527]). In Escherichia coli K12, the domain is found in YibJ, which may be a pseudogene. The family is predominantly found in Actinomycetota, particularly Pseudonocardiaceae, and also in Proteobacteria. The function of this domain remains to be determined. Shows similarity to SteB family [pfam:PF29776] and [pfam:PF14252].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0093","name":"Peptidase_CD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":185,"interactions":0,"matches":968,"pathways":0,"proteins":819,"proteomes":632,"sets":1,"structural_models":{"alphafold":215},"structures":0,"taxa":1086},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":405},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}