This entry represents a domain of unknown function found in bacterial proteins. The function of this domain remains to be determined. The predicted structure shows strong similarity to dipeptidyl peptidase III. This suggests proteins of this family are likely to be peptidase enzymes.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0126","name":"Peptidase_MA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":1483,"pathways":0,"proteins":1483,"proteomes":1278,"sets":1,"structural_models":{"alphafold":1004},"structures":2,"taxa":2481},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":797},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5zum","name":"Structure of dipeptidyl-peptidase III from Corallococcus sp. strain EGB"}}}