This domain is found in uncharacterised prokaryotic proteins. In most of these proteins this domain is flanked by a P-loop ATPase-like domain from the N-termini and by Restriction endonuclease-like domain at the C-termini. The domain represented by this entry has significant to known winged helix domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":10626,"pathways":0,"proteins":10626,"proteomes":4109,"sets":1,"structural_models":{"alphafold":7658},"structures":0,"taxa":7338},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":120,"alignment:full":6612},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}