This entry represents the N-terminal zinc binding domain found in bacteriophage and bacterial proteins. These proteins typically contain this N-terminal zinc binding domain, a C-terminal HNH domain with likely nuclease activity ([pfam:PF01844]). The specific function of this N-terminal zinc binding domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163736":{"PMID":23125367,"ISBN":null,"volume":"41","issue":"1","year":2013,"title":"Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease.","URL":null,"raw_pages":"378-90","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Xu SY","Gupta YK."],"DOI_URL":"https://doi.org/10.1093/nar/gks1043"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1194,"pathways":0,"proteins":1194,"proteomes":987,"sets":0,"structural_models":{"alphafold":640},"structures":2,"taxa":1997},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":685},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}