This entry represents the N-terminal beta barrel domain found in DUF3723 proteins found mainly in fungi. This domain is frequently encoded within Starship elements, which are large transposable elements that mobilise accessory genes in fungal genomes [[cite:PUB00163731]]. This domain shows structural similarity to bacterial proteins involved in chromosome stabilisation such as ParB. This suggests this domain may bind to CTP. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163731":{"PMID":37023132,"ISBN":null,"volume":"120","issue":"15","year":2023,"title":"Starships are active eukaryotic transposable elements mobilized by a new family of tyrosine recombinases.","URL":null,"raw_pages":"e2214521120","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Urquhart AS","Vogan AA","Gardiner DM","Idnurm A."],"DOI_URL":"https://doi.org/10.1073/pnas.2214521120"}},"set_info":{"accession":"CL0248","name":"ParB_Srx"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":1291,"pathways":0,"proteins":1288,"proteomes":472,"sets":1,"structural_models":{"alphafold":1020},"structures":0,"taxa":1054},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":184,"alignment:full":1156},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}