This entry represents a small integral membrane domain of approximately 50-70 amino acids with two predicted transmembrane helices. The family is found exclusively in halophilic archaea, restricted to the order Halobacteriales, particularly the families Haloferacaceae, Natrialbaceae and Haloarculaceae. Some members are found in proteins containing PEP-CTERM protein-sorting domains. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":242,"pathways":0,"proteins":242,"proteomes":242,"sets":0,"structural_models":{"alphafold":235},"structures":0,"taxa":374},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":101},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}