This entry represents an immunoglobulin-like domain found in outer membrane proteins of spirochaetes, particularly Treponema species. The domain is approximately 90-100 residues long and adopts the characteristic Ig-like fold consisting of two beta-sheets arranged in a sandwich configuration. These proteins are typically bipartite, containing this N-terminal periplasmic Ig-like domain and a C-terminal domain. The domain is found in proteins predicted to be outer membrane lipoproteins. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163735":{"PMID":25894582,"ISBN":null,"volume":"10","issue":"4","year":2015,"title":"Identification of functional candidates amongst hypothetical proteins of Treponema pallidum ssp. pallidum.","URL":null,"raw_pages":"e0124177","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Naqvi AA","Shahbaaz M","Ahmad F","Hassan MI."],"DOI_URL":"https://doi.org/10.1371/journal.pone.0124177"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":36,"pathways":0,"proteins":36,"proteomes":36,"sets":1,"structural_models":{"alphafold":30},"structures":0,"taxa":78},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":33},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}