{"metadata":{"accession":"PF29233","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061588","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8518)","short":"DUF8518"},"description":[{"text":"<p>This entry represents a domain of unknown function found in spirochaetes, predominantly Treponema and Spirochaeta species. The domain is approximately 70 residues in length and is found N-terminal to a peptidase M15 domain ([pfam:PF13539]). The function of this domain remains to be determined.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":46,"pathways":0,"proteins":46,"proteomes":41,"sets":0,"structural_models":{"alphafold":43},"structures":0,"taxa":92},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":39},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}