This entry represents an N-terminal domain of approximately 90-100 residues found in serine proteases from spirochaetes, predominantly Treponema species. The domain is located N-terminal to a trypsin-like serine protease domain ([pfam:PF00089], [pfam:PF13365]) and is typically followed by one or two C-terminal PDZ domains. Members include the periplasmic serine protease TP0546 from Treponema pallidum. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":32,"pathways":0,"proteins":32,"proteomes":31,"sets":0,"structural_models":{"alphafold":27},"structures":0,"taxa":66},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":29},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}