This entry represents a C-terminal domain of approximately 40 residues found in anti-sigma factor antagonist proteins from spirochaetes, predominantly from Treponema and Leptospira species. The domain contains conserved cysteine residues in a CPIC...CSEC motif, suggesting potential metal binding. Anti-sigma factor antagonist proteins regulate sigma factor activity in bacterial stress responses. The protein TP0233 from Treponema pallidum has been shown to interact with flagellar motor components [[cite:PUB00163734]]. The specific function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163734":{"PMID":17667950,"ISBN":null,"volume":"3","issue":null,"year":2007,"title":"The protein network of bacterial motility.","URL":null,"raw_pages":"128","medline_journal":"Mol Syst Biol","ISO_journal":"Mol Syst Biol","authors":["Rajagopala SV","Titz B","Goll J","Parrish JR","Wohlbold K","McKevitt MT","Palzkill T","Mori H","Finley RL Jr","Uetz P."],"DOI_URL":"https://doi.org/10.1038/msb4100166"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":226,"pathways":0,"proteins":226,"proteomes":122,"sets":0,"structural_models":{"alphafold":158},"structures":0,"taxa":234},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":67},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}