This entry represents a domain of unknown function found in large multi-domain proteins. The domain is typically located between N-terminal domains, such as lamin tail domains ([pfam:PF00932]) or cadherin-like domains, and C-terminal regions containing endonuclease/exonuclease ([pfam:PF03372], [pfam:PF19580]) or calcium-binding repeat domains ([pfam:PF00353]). The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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