This entry represents a helical domain found in association with a G domain (also known as MMR_HSR1 or GTP-binding domain), a conserved nucleotide-binding domain that typically binds GTP. This domain is found predominantly in fungal species across both Basidiomycota and Ascomycota phyla. The function of this domain is unknown. Structure predictions suggest it may adopt a HTH fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":21,"interactions":0,"matches":852,"pathways":0,"proteins":848,"proteomes":239,"sets":1,"structural_models":{"alphafold":759},"structures":0,"taxa":578},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":781},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}