{"metadata":{"accession":"PF29061","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061568","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8498)","short":"DUF8498"},"description":[{"text":"<p>This domain is found at the N-terminal end of a group of fungal uncharacterised proteins. This domain adopts a immunoglobulin -like fold. Its function is unknown.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00163733":{"PMID":36427319,"ISBN":null,"volume":"8","issue":"47","year":2022,"title":"Conformational changes in mitochondrial complex I of the thermophilic eukaryote <i>Chaetomium thermophilum</i>.","URL":null,"raw_pages":"eadc9952","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Laube E","Meier-Credo J","Langer JD","Kuhlbrandt W."],"DOI_URL":"https://doi.org/10.1126/sciadv.adc9952"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":773,"pathways":0,"proteins":750,"proteomes":730,"sets":1,"structural_models":{"alphafold":632},"structures":3,"taxa":1431},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":108,"alignment:full":622},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}