This entry represents an N-terminal putative sensor domain found in histidine kinase proteins. This domain precedes the histidine kinase A (HisKA) phosphoacceptor domain ([pfam:PF00512]) and the histidine kinase ATPase C-terminal domain ([pfam:PF02518]). The domain is approximately 145-155 residues in length. This family is found predominantly in Bacteroidota, particularly in the orders Flavobacteriales, Cytophagales and Sphingobacteriales. The function of this sensor domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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