This entry represents a small domain of unknown function. It includes Porphyromonas gingivalis protein PGN_1290 [swissprot:B2RGS5] which was found to be down-regulated in a GppX mutant [[cite:PUB00163732]]. This domain is composed of a four stranded beta sheet (strand order 1-4-3-2) with two alpha helices packed on one side. AlphaFold3 suggests these proteins form confident homodimers ([swissprot:R9HNH3] ipTM=0.9 pTM=0.92).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163732":{"PMID":23194602,"ISBN":null,"volume":"28","issue":"1","year":2013,"title":"Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.","URL":null,"raw_pages":"70-81","medline_journal":"Mol Oral Microbiol","ISO_journal":"Mol Oral Microbiol","authors":["Hirano T","Beck DA","Wright CJ","Demuth DR","Hackett M","Lamont RJ."],"DOI_URL":"https://doi.org/10.1111/omi.12007"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":283,"pathways":0,"proteins":283,"proteomes":137,"sets":0,"structural_models":{"alphafold":200},"structures":0,"taxa":237},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":166},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}