This entry represents a small SH3-like beta-barrel domain found N-terminal to the Smr domain ([pfam:PF01713]) in DNA mismatch repair proteins from Bacteroidota. The domain is approximately 50 residues in length and is found predominantly in Flavobacteriaceae, Sphingobacteriaceae and Cytophagales families. The Smr domain itself is involved in DNA mismatch repair processes. The specific function of this N-terminal domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1822,"pathways":0,"proteins":1822,"proteomes":1820,"sets":1,"structural_models":{"alphafold":1187},"structures":0,"taxa":2357},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":195,"alignment:full":835},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}