This entry represents the second domain found in bacterial DNA primases, positioned between the N-terminal zinc ribbon domain ([pfam:PF01807]) and the C-terminal Toprim domain ([pfam:PF13155]). This domain is approximately 65-70 amino acids in length and is found predominantly in DNA primases from Bacteroidota species, particularly members of the Bacteroidales order. DNA primase (DnaG) synthesises RNA primers that are utilised by DNA polymerase during bacterial chromosomal DNA replication. The specific function of this middle domain remains to be determined, but its conservation suggests it plays an important structural or functional role in primase activity within these bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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