{"metadata":{"accession":"PF28795","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061532","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8462)","short":"DUF8462"},"description":[{"text":"<p>This is a HTH domain found in a group of uncharacterised sequences from bacteria and archaea, including the Uncharacterized HTH-type transcriptional regulator MJ0774 from Methanocaldococcus jannaschii.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":16,"interactions":0,"matches":2789,"pathways":0,"proteins":2775,"proteomes":2249,"sets":1,"structural_models":{"alphafold":1727},"structures":0,"taxa":3342},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":180,"alignment:full":1441},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}