This entry represents a small helical domain of unknown function found in proteins from Flavobacteriia. The domain is typically around 70-90 residues in length and is located towards the C-terminus of these proteins, following a short N-terminal region. The proteins are found almost exclusively in the Flavobacteriaceae family within the Bacteroidota phylum. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1940,"pathways":0,"proteins":1940,"proteomes":1939,"sets":0,"structural_models":{"alphafold":1258},"structures":0,"taxa":2567},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":154,"alignment:full":919},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}