{"metadata":{"accession":"PF28717","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061516","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8446)","short":"DUF8446"},"description":[{"text":"<p>This is a domain found at the N-terminal of a group of uncharacterised fungal sequences which is found in association with a Cytidyltransferase-like domain ([pfam:PF01467]) at the C-terminal. This domain seems to adopt a structure similar to those in the HUP superfamily.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0039","name":"HUP"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":867,"pathways":0,"proteins":866,"proteomes":828,"sets":1,"structural_models":{"alphafold":728},"structures":0,"taxa":1625},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":159,"alignment:full":696},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}