This entry represents a conserved domain found at the C-terminus of S41 family carboxyl-terminal processing peptidases in members of the phylum Bacteroidota. The domain is approximately 85-90 amino acids in length and is located immediately downstream of the Peptidase_S41 catalytic domain ([pfam:PF03572]). S41 family peptidases are serine proteases involved in C-terminal processing of proteins, including the removal of C-terminal extensions from penicillin-binding proteins and other substrates. This C-terminal domain is found exclusively in Bacteroidota, particularly in the classes Bacteroidia, Flavobacteriia, Cytophagia and Sphingobacteriia, suggesting it may confer phylum-specific functionality or substrate specificity. The domain architecture of these proteins typically consists of an N-terminal CtpB_N-like domain ([pfam:PF22694]), one or more PDZ domains ([pfam:PF00595], [pfam:PF13180], [pfam:PF17820]), the catalytic Peptidase_S41 domain, and this C-terminal domain. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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