{"metadata":{"accession":"PF28543","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059479","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8435)","short":"DUF8435"},"description":[{"text":"<p>This domain is found in a group of uncharacterised proteins from worms. This domain has highly conserved motifs YRF and HLRxRK and is predicted to show high structural similarity with UBA domains, which are often involved in ubiquitin binding. It is often found associated with [pfam:PF00650].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0214","name":"UBA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":287,"pathways":0,"proteins":287,"proteomes":106,"sets":1,"structural_models":{"alphafold":278},"structures":0,"taxa":239},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":236},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}