{"metadata":{"accession":"PF28514","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059466","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8422)","short":"DUF8422"},"description":[{"text":"<p>This domain is found in uncharacterised metazoan proteins. It is predicted to adopt a non-compact structure composed mainly of alpha-helices. This domain is sometimes found in combination with [pfam:PF00078] and [pfam:PF26215].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":378,"interactions":0,"matches":4452,"pathways":0,"proteins":4394,"proteomes":322,"sets":0,"structural_models":{"alphafold":2774},"structures":0,"taxa":1497},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":2308},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}