This domain is found in uncharacterised fungal proteins. It contains several highly conserved cysteine and histidine residues that may coordinate a metal ion. These residues come close in space and are predicted to form substructures each of which is reminiscent of treble-clef zinc fingers.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0839","name":"Tbcl_zf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":271,"pathways":0,"proteins":223,"proteomes":216,"sets":1,"structural_models":{"alphafold":131},"structures":0,"taxa":397},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":222},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}