{"metadata":{"accession":"PF28497","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059460","hierarchy":null,"name":{"name":"Family of unknown function (DUF8416)","short":"DUF8416"},"description":[{"text":"<p>This family represents an uncharacterised domain found in bacterial proteins from the Bacteroidota phylum, particularly in members of Flavobacteriaceae and Sphingobacteriaceae. The domain typically spans approximately 90-100 residues and is positioned between the TMEM260-like domain ([pfam:PF11028]) and the TMEM260_2 domain ([pfam:PF28495]) in the protein architecture. These proteins appear to be glycosyltransferases or related membrane proteins. The function of this domain remains to be determined.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":2539,"pathways":0,"proteins":2539,"proteomes":2033,"sets":0,"structural_models":{"alphafold":1646},"structures":0,"taxa":2685},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":332,"alignment:full":1208},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}