This domain is found in a group of uncharacterised proteins mainly found in actinomycetes. This domain, which contains highly conserved W, D, G residues and a conserved motif FxHRHR, is predicted to form an antiparallel beta sheet and alpha helices. Bet_v_1 domains contain a hydrophobic ligand-binding pocket [[cite:PUB00053295]]. The specific function of this family is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00053295":{"PMID":18922149,"ISBN":null,"volume":"8","issue":null,"year":2008,"title":"The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands.","URL":null,"raw_pages":"286","medline_journal":"BMC Evol Biol","ISO_journal":"BMC Evol. Biol.","authors":["Radauer C","Lackner P","Breiteneder H."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2148-8-286"}},"set_info":{"accession":"CL0209","name":"Bet_v_1_like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":542,"pathways":0,"proteins":542,"proteomes":519,"sets":1,"structural_models":{"alphafold":345},"structures":0,"taxa":1024},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":54,"alignment:full":267},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}