This domain is found in uncharacterised proteins from bacteria and eukaryotes. It is predicted to fold into an alpha/beta structure composed of four-stranded antiparallel beta-sheet with strand order 2341 and alpha helices packed on one face of the sheet. This domain contains two pair of highly conserved cysteine residues that are predicted to form disulfide bonds. It is frequently found N-terminal to TIM-barrel domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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