This domain is found C-terminal in uncharacterised bacterial proteins. It is predicted to fold into L-shaped beta-sandwich. Most proteins containing this domain also contain a lipoprotein lipid attachment site at the N-terminus suggesting they may be associated with the membrane.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":103,"pathways":0,"proteins":103,"proteomes":97,"sets":0,"structural_models":{"alphafold":63},"structures":0,"taxa":163},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":53},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}