{"metadata":{"accession":"PF28443","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059445","hierarchy":null,"name":{"name":"Family of unknown function (DUF8401)","short":"DUF8401"},"description":[{"text":"<p>This entry represents a conserved cysteine-rich region found in uncharacterised metazoan proteins. The conserved cysteine residues are predicted to form disulfide bonds.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":88,"interactions":0,"matches":2256,"pathways":0,"proteins":1938,"proteomes":179,"sets":0,"structural_models":{"alphafold":1590},"structures":0,"taxa":845},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":1513},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}