This entry represents a family of proteins that were formerly part of the DUF3316 family. However, the family contained two unrelated groups of proteins. These members are split into this new family. The domain contains a three stranded beta sheet with a longer and shorter alpha helix packed on one side. The function of these proteins is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":233,"pathways":0,"proteins":233,"proteomes":136,"sets":0,"structural_models":{"alphafold":154},"structures":0,"taxa":188},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":72},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}