This domain is found in uncharacterised fungal proteins. It is predicted to fold into an alpha/beta structure composed of an open beta-barrel with alpha-helices packed on one side. It contains highly conserved G[FWY][DE] sequence motif that may be important for function.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":156,"interactions":0,"matches":1167,"pathways":0,"proteins":1148,"proteomes":509,"sets":0,"structural_models":{"alphafold":617},"structures":0,"taxa":1032},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":223,"alignment:full":919},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}