This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an alpha/beta structure composed of a central five-stranded mixed beta-sheet and alpha-helices packed on both sides. This domain has a significant structural similarity to domains members of PD-(D/E)XK nuclease superfamily that extends to the active site architecture suggesting that this domain may possess endonuclease activity. This domain is frequently found in combination with [pfam:PF28123] (DUF8370).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":570,"pathways":0,"proteins":570,"proteomes":504,"sets":1,"structural_models":{"alphafold":334},"structures":0,"taxa":1264},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":119,"alignment:full":303},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}