This domain is found in uncharacterised fungal proteins. It is predicted to fold into an alpha/beta structure composed of a four-stranded antiparallel beta-sheet packed on both sides with alpha-helices. It also contains a long alpha-hairpin, stabilised by conserved interactions, which is inserted after the first strand and may be functionally important. In addition, it contains a highly conserved KTGYx(5-6)[FW]DLD sequence motif which may constitute a part of a binding interface.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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