This domain is found in uncharacterised proteins from bacteria and eukaryotes. It is predicted to fold into a globular structure composed of a mixed beta-sheet and alpha-helices packed on both sides of it. It contains several conserved cysteine residues which are predicted to form disulfide bonds. In addition, there highly conserved aspartate, glutamate and histidine residues suggesting that some members may have enzymatic activity.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0927","name":"Y4gN-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":187,"pathways":0,"proteins":169,"proteomes":59,"sets":1,"structural_models":{"alphafold":129},"structures":0,"taxa":249},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":131},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}