This domain is found in uncharacterised proteins mainly from Gram negative bacteria. It is predicted to fold into an alpha-beta-beta architecture featuring two sandwiched beta-sheets and alpha-helices packed on one side. This domain contains several negatively charged residues which are located on the domain surface and highly conserved.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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