{"metadata":{"accession":"PF27094","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059390","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8346)","short":"DUF8346"},"description":[{"text":"<p>This entry represents a Leucine Rich domain in uncharacterised proteins mainly from animals. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0022","name":"LRR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":249,"pathways":0,"proteins":247,"proteomes":7,"sets":1,"structural_models":{"alphafold":238},"structures":0,"taxa":49},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":110},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}