{"metadata":{"accession":"PF27040","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059386","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8342)","short":"DUF8342"},"description":[{"text":"<p>This entry represents a domain of unknown function at the N-terminal in uncharacterised eukaryotic proteins mainly from Trypanosoma. This domain contains a RNase-like fold. The core architecture typically features a central five-stranded beta-sheet flanked by several alpha-helices. This domain can be found associated with [pfam:PF01612].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":31,"pathways":0,"proteins":31,"proteomes":28,"sets":1,"structural_models":{"alphafold":6},"structures":0,"taxa":66},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":19},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}