This entry represents a domain of unknown function at the C-terminal in uncharacterised proteins mainly from Pseudomonadati. This domain contains a RNase like fold. The core architecture typically features a central five-stranded beta-sheet flanked by several alpha-helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":152,"pathways":0,"proteins":152,"proteomes":151,"sets":1,"structural_models":{"alphafold":112},"structures":0,"taxa":227},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":61,"alignment:full":72},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}