This entry represents a domain of unknown function at the N-terminal in uncharacterised fungal proteins. This domain contains a RNases-like fold. The core architecture typically features a central five-stranded beta-sheet flanked by several alpha-helices. Most RNases H also possess an active site with a conserved DEDD motif (aspartate and glutamate residues), essential for coordinating catalytically required metal ions, usually Mg [[cite:PUB00016297]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016297":{"PMID":8696976,"ISBN":null,"volume":"6","issue":"1","year":1996,"title":"Retroviral integrases and their cousins.","URL":null,"raw_pages":"76-83","medline_journal":"Curr Opin Struct Biol","ISO_journal":"Curr. Opin. Struct. Biol.","authors":["Rice P","Craigie R","Davies DR."],"DOI_URL":"http://dx.doi.org/10.1016/S0959-440X(96)80098-4"}},"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":31,"pathways":0,"proteins":31,"proteomes":18,"sets":1,"structural_models":{"alphafold":28},"structures":0,"taxa":52},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":22},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}