This entry represents a domain of unknown function in uncharacterised proteins mostly found in Sar organisms. These proteins contain a SNARE-like fold. They are characterised by their tetrameric coiled-coil structures that facilitate membrane fusion processes. SNARE proteins are present in synaptic terminals, endoplasmic reticulum, and Golgi apparatus where the coiled-coil structure is important for membrane targeting and fusion specificity. The conserved coiled-coil architecture enables these proteins to function in vesicle trafficking and membrane fusion events [[cite:PUB00161918]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00161918":{"PMID":32924745,"ISBN":null,"volume":"17","issue":"10","year":2021,"title":"New insights regarding SNARE proteins in autophagosome-lysosome fusion.","URL":null,"raw_pages":"2680-2688","medline_journal":"Autophagy","ISO_journal":"Autophagy","authors":["Tian X","Teng J","Chen J."],"DOI_URL":"https://doi.org/10.1080/15548627.2020.1823124"}},"set_info":{"accession":"CL0445","name":"SNARE-fusion"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":22,"pathways":0,"proteins":22,"proteomes":22,"sets":1,"structural_models":{"alphafold":2},"structures":0,"taxa":46},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":23},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}