This domain is found in uncharacterised bacterial proteins. It contains several highly conserved cysteine and histidine residues that may be involved in metal coordination. This domain is predicted to fold into a structure that resembles a double zinc ribbon domain with swapped knuckles.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":35,"pathways":0,"proteins":35,"proteomes":33,"sets":1,"structural_models":{"alphafold":28},"structures":0,"taxa":92},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":18},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}