This entry represents a domain of unknown function in putative Ig-domain-containing proteins mainly from animals. This domain contains a Spectrin fold with a conserved three-helix bundle structure that is typically arranged in tandem repeats. These repeats confer mechanical flexibility and structural resilience, allowing the proteins to maintain cell shape and organisation. Spectrin-repeat proteins form elongated scaffolds beneath the plasma membrane and contribute to cytoskeletal integrity and membrane stability [[cite:PUB00161917]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00161917":{"PMID":27698030,"ISBN":null,"volume":"8","issue":"10","year":2016,"title":"Cytoskeletal Integrators: The Spectrin Superfamily.","URL":null,"raw_pages":"a018259","medline_journal":"Cold Spring Harb Perspect Biol","ISO_journal":"Cold Spring Harb Perspect Biol","authors":["Liem RK."],"DOI_URL":"https://doi.org/10.1101/cshperspect.a018259"}},"set_info":{"accession":"CL0743","name":"Spectrin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":126,"pathways":0,"proteins":126,"proteomes":87,"sets":1,"structural_models":{"alphafold":47},"structures":0,"taxa":206},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":102},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}