This domain is found in uncharacterised proteins mainly from Trypanosomatidae species. It is predicted to fold into a beta-barrel structure that is reminiscent to the beta-barrel observed in VirK family proteins [pfam:PF06903]. These two barrels, however, relate not only by circular permutation but also by strand flip with a change of directionality.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":29,"pathways":0,"proteins":29,"proteomes":27,"sets":0,"structural_models":{"alphafold":28},"structures":0,"taxa":63},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":17},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}