{"metadata":{"accession":"PF26799","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR059312","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8268)","short":"DUF8268"},"description":[{"text":"<p>This entry represents a domain from a family of uncharacterised proteins in the Archaea. The domain is predominantly found in members of the Methanobacteriota phylum, specifically within the Halobacteria class. Proteins containing this domain are typically integral membrane proteins with two transmembrane helices. The domain is approximately 60-70 amino acids in length. This domain is sometimes associated with [pfam:PF09997].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":501,"pathways":0,"proteins":501,"proteomes":286,"sets":0,"structural_models":{"alphafold":474},"structures":0,"taxa":453},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":75,"alignment:full":197},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}