This domain is found in uncharacterised proteins from Halobacteria. It is predicted to fold into an alpha/beta structure composed of a small four stranded antiparallel beta-sheet and alpha-helices packed on one side of it. It contains two conserved sequence motifs IPLH and RxRFW which may have functional importance. This domain is frequently found in combination with domains members of AAA superfamily.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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